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In the kidney, EP2 is present in peritubular fibroblasts and stimulates the tubular reabsorption of glucose and solutes, by mechanisms that are poorly understood. The EP2 receptor is also detected in secretory organs such as exocrine glands, where it regulates exocytosis and ion transport. In vascular smooth muscle, PGE(2) acts through EP2 to enhance adenylate cyclase activity and is a potent vasodilator. In colon and stomach, PGE(2) is secreted from epithelial cells and stimulates adenylate cyclase by an EP2 receptor. The prostaglandin (PG) E(2) receptor EP2 is widely expressed in the digestive system and is the most selective receptor subtype for PGE(2) that enhances adenylate cyclase activity. Modulation of cyclic AMP metabolism by the prostaglandin E(2) receptor EP2 subtype.
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